Studies & Publications

2013

• Roggenkamp D, Köpnick S, Stäb F, Wenck H, Schmelz M, Neufang G: Epidermal Nerve Fibers Modulate Keratinocyte Growth via Neuropeptide Signaling in an Innervated Skin Model. J Invest Dermatol. 2013 [Epub ahead of print]

• Kolbe L, Mann T, Gerwat W, Batzer J, Ahlheit S, Scherner C, Wenck H, Stäb F: 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. J Eur Acad Dermatol Venereol. 27 Suppl 1:19-23, 2013

• Mess A, Enthaler B, Fischer M, Rapp C, Pruns JK, Vietzke JP: A novel sampling method for identification of endogenous skin surface compounds by use of DART-MS and MALDI-MS. Talanta 103: 398-402, 2013

• Schweiger D, Rippke F, Drescher P, Braren S, Lüttke J, Filbry A, Max H: Highly Efficient Rinse-Off/Leave-On Scalp Care Treatments to Reduce Moderate to Severe Dandruff. Journal of Cosmetics. Dermatological Sciences and Applications 3, 46-55; 2013

• Enthaler B, Trusch M, Fischer M, Rapp C, Pruns JK, Vietzke JP: MALDI imaging in human skin tissue sections: focus on various matrices and enzymes. Anal Bioanal Chem. 405(4): 1159-70, 2013

• Hildebrand J, Grundhoff A, Gallinat S, Wenck H, Knott A: MicroRNA Profiling During Human Keratinocyte Differentiation Using a Quantitative Real-Time PCR Method. Methods Mol Biol. 2013; 961:193-200.

2012

• Diercks BP, Hauschildt I, Stäb F, Wenck H, Döring O, Peters N. IL-10 promotes secretion of S100A8/A9 from human monocytes trough an inclusion in plasma membranes. Scand J Immunol. 2012 [Epub ahead of print]

• Pfannenbecker U, Bessou-Touya S, Faller C, Harbell J, Jacob T, Raabe H, Tailhardat M, Alépée N, De Smedt A, De Wever B, Jones P, Kaluzhny Y, Le Varlet B, McNamee P, Marrec-Fairley M, Van Goethem F: Cosmetics Europe multi-laboratory pre-validation of the EpiOcular™ reconstituted human tissue test method for the prediction of eye irritation. Toxicol In Vitro. 2012 [Epub ahead of print]

• Ruetze M, Knauer T, Gallinat S, Wenck H, Achterberg V, Maerz A, Deppert W, Knott A: A novel niche for skin derived precursors in non-follicular skin. J Dermatol Sci. 2012 [Epub ahead of print]

• Hagens R: Letter to the editor. J Cosmet Sci. 2012 Nov-Dec;63(6):409-12.

• Winnefeld M, Lyko F: The aging epigenome: DNA methylation from the cradle to the grave. Genome Biol. 2012 Jul 30;13(7):165.

• Spörl F, Korge S, Jürchott K, Wunderskirchner M, Schellenberg K, Heins S, Specht A, Stoll C, Klemz R, Maier B, Wenck H, Schrader A, Kunz D, Blatt T, Kramer A: Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10903-8

• Hagemann S, Brönneke S, Winnefeld M: Implications of epigenetic mechanisms for vascular development and disease (editorial) Epigenomics 2012, Oct;4(5):475-7. 

• Söhle J, Machuy N, Smailbegovic E, Wessel S, Gonda L, Wenck H, Stäb F, Winnefeld M: Identification of New Genes Involved in Human Adipogenesis and Fat Storage. PLoS One 2012;7(2):e31193.

• Winnefeld M, Brueckner B, Grönniger E, Stäb F, Wenck H, Lyko F: Stable ethnic variations in DNA methylation patterns of human skin. J Invest Dermatol. 2012 Feb;132(2):466-8.

• Winnefeld M: Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin. Oral presentation at 2nd international conference on Variations of Hair & Skin: Ethnicity, Age & Health.2011, Princeton, USA

• Kolbe L: How much sun protection is needed?: Are we on the way to full-spectrum protection? J Invest Dermatol. 132:1756-7, 2012

• Hildebrand J, Spörl F, Korge S, Gallinat S, Wenck H, Deppert W, Knott A, Blatt T: Cell cycle regulator Cdkn1c (p57/KIP2) shows distinct expression in epidermal differentiation. Eur J Dermatol. 2012 Sep-Oct;22(5):694-6.

• Reinheimer K, Grosso M, Hetzel F, Kübel J, Wilhelm M: Fourier Transform Rheology as an innovative morphological characterization technique for the emulsion volume average radius and its distribution. Journal of Colloid and Interface Science 2012;380(1):201-12.

• Reinheimer K, Grosso M, Kübel J, Hetzel F, Wilhelm M: Fourier Transform Rheology as a noninvasive characterization technique for emulsions. Proceedings of the 6th International Symposium on Food Rheology and Structure (ISFRS); Kerschensteiner Verlag 45 (2012)

• Schrader A, Siefken W, Breitenbach U, Gatermann C, Sperling G, Biernoth T, Scherner C, Stäb F, Wenck H, Wittern K-P, Blatt T: Effects of Glyceryl Glucoside on AQP3 Expression, Barrier Function and Hydration of Human Skin. Skin Pharmacol Physiol 25: 192-199, 2012

• Aeby P, Alépée N, Ashikaga T, Bessou-Touya S, Dufour E, Gerberick F, Gilmour N, Goebel C, Kern P, Marrec-Fairley M, Martinozzi-Teissier S, Maxwell G, Sakaguchi H, Scheel J, Schepky A, Reisinger K, Tailhardat M, Winkler P: The Colipa Research and Method Development Program for identifying and Characterizing Skin Sensitizers without Animal Testing. ALTEX Proceedings, 2012

• Schepky A, Wenck H, Reuter H: Considerations for the Development of an Integrated Testing Stragegy for Skin Sensitization. ALTEX Proceedings, 2012

• Haag M, Hamann T, Kulle A, Riepe F, Blatt T, Wenck H, Holterhus P-M, Peirano, R: Age and skin site related differences in steroid metabolism in male skin point to a key role of sebocytes in cutaneous hormone metabolism. Dermato-Endocrinology 4:1, 1-7, 2012

• Goodman JI, Hayes WA, Korte F, Lotti M, Pariza M, Rulis A, Satoh T, Schepky A: Regulatory Toxicology and Pharmacology. SciVerse ScienceDirect, 2012

• Tschierske, N, Emeis, D, Biel, SS: Efficacy loss of antimicrobial actives in emulsions. SOFW Journal 138, 2-6, 2012

• Lutz V, Sattler M, Gallinat S, Wenck H, Poertner R, Fischer F: Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence. Skin Res Technol, 18: 168-179, 2012

• Puschmann S, Rahn C, Wenck H, Gallinat S, Fischer F: Approach to quanitify human dermal skin aging using multiphoton laser scanning microscopy. J Biomed Opt. 17:036005, 2012

• Hagmeister U, Reuschlein K, März A, Wenck H, Gallinat S, Lucius R, Knott A: Poly(A) tail shortening correlates with mRNA repression in tropoelastin regulation. J Dermatol Sci. 67:44-50, 2012

• Brönneke S, Brückner B, Peters N, Bosch T, Stäb F, Wenck H, Hagemann S,Winnefeld M: DNA methylation regulates lineagespecifying genes in primary lymphatic and blood endothelial cells. Angiogenesis 15(2):317-29, 2012

• Roggenkamp D, Falkner S, Stäb F, Petersen M, Schmelz M, Neufang G: Atopic Keratinocytes Induce Increased Neurite Outgrowth in a Coculture Model of Porcine Dorsal Root Ganglia Neurons and Human Skin Cells. J Invest Dermatol. 2012 Mar 15.

• Navid F, Kolbe L, Stäb F, Korff T, Neufang G: UV radiation induces the release of angiopoietin-2 from dermal microvascular endothelial cells. Exp Dermatol. 21:147-53, 2012

• Basketter DA Clewell H, Kimber I, Rossi A, Blaauboer B, Burrier R, Daneshian M, Eskes C, Goldberg A, Hasiwa N, Hoffmann S, Jaworska J , Knudsen TB, Landsiedel R, Leist M, Locke P, Maxwell G, McKim J, McVey EA, Ouédraogo G, Patlewicz G, Pelkonen O, Roggen E, Rovida C, Ruhdel I, Schwarz M, Schepky A, Schoeters G, Skinner N, Trentz K, Turner M, Vanparys P, Yager J, Zurlo J, Hartung T: A Roadmap for the Development of Alternative (Non-Animal) Methods for Systemic Toxicity Testing. ALTEX 29, 2012

• Peirano R, Hamann T, Düsing H-J, Akhiani M, Koop U, Schmidt-Rose T, Wenck H: Topically applied L-carnitine effectively reduces sebum secretion in human skin. Journal of Cosm Dermatol, 11, 30-36, 2012

• Peirano Ro I, Achterberg V, Düsing H-J, Akhiani M, Koop U, Jaspers S, Krüger A, Schwengler H, Hamann T, Wenck H, Stäb F, Gallinat S, Blatt T: Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. Journal of Cosmetic Dermatology, 10, 273-281, 2012

• Enthaler, B, Pruns, J, Wessel, S, Rapp, C, Fischer, M, Wittern, KP, Improved sample preparation for MALDI–MSI of endogenous compounds in skin tissue sections and mapping of exogenous active compounds subsequent to ex-vivo skin penetration. Analytical and Bioanalytical Chemistry. 402: 1159-1167, 2012

• Weber TM, Kausch M, Rippke F, Schoelermann AM, Filbry AW: Treatment of Xerosis with a Topical Formulation Containing Glyceryl Glucoside,Natural Moisturizing Factors, and Ceramide. J Clin Aesthet Dermatol.;5:29–39, 2012

2011   
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• Matthias Vockel, Simone Pollok, Ute Breitenbach, Ina Ridderbusch, Hans-Jürgen Kreienkamp, Johanna M. Brandner: Somatostatin Inhibits Cell Migration and Reduces Cell Counts of Human Keratinocytes and Delays Epidermal Wound Healing in an Ex Vivo Wound Model. PLOS ONE, May 2011, Volume 6, Issue 5, e19740
  
  
• S. Conzelmann, B. Traupe, R. I. Peirano, T. Schläger, F. rippke, G. Neufang: Clinical and Dermatological Studies on Medical Skin and wound Care. Poster Presentations at the 20th EADV Congress Lisbon 2011
  
  
• Hetzel F, Rößler, K, Brummer, R: Rheo-optische Charakterisierung von kosmetischen Schäumen, Buchbeitrag "Seminarband Würzburger Tage 2010" ISBN 978-3-940184-08-5
  
  
• Mess, A, Vietzke, JP, Rapp C, Franke, W: Qualitative analysis of tackifier resins in pressure sensitive adhesives using direct analysis in real time time-of-flight mass spectrometry. Analytical Chemistry (accepted 24.08.2011)
  
  
• Meinke, M., Richter, H., Schanzer, S., Bohnsack, K., Presto, S., Filbry, A., Rippke, F., Vogt, A., Lademann, J.: Penetration of topically applied pollen allergens into Langerhans cells in barrier disrupted human skin and a prevention method. Exp. Dermatol. 2011, 20: 164
  
  
• Grotheer, E., Heinsohn, G., Rapp, C., Presto, S., Rippke, F., Uhlmann, B., Conzelmann, S.: A novel method to educate patients how to apply a sufficient amount of sunscreen aided by in vivo attenuated total reflection FT-IR spectroscopic imaging. Exp. Dermatol. 2011, 20: 193
  
  
• Schölermann, A., Scherdin, U., Filbry, A., Presto, S., Rippke, F.: Efficacy of three new anti-wrinkle face care creams with urea and hyaluronic acid. Exp. Dermatol. 2011, 20: 207
  
  
• Scherdin, U., Traupe, B., Schulz, J., Presto, S., Rippke, F., Filbry, A.: Results of in vitro and in vivo studies with a novel shave and after shave regimen. Exp. Dermatol. 2011, 20: 207
  
  
• S. Conzelmann, B. Traupe, R. I. Peirano, T. Schläger, F. Rippke, G. Neufang: A new skin care approach for acne prone skin, Poster EADV (2011)
  
  
• K. Bohnsack, A.-K. Fiege, U. Dickschat, A. Filbry, F. Rippke, R. Fölster-Holst: Preventive efficacy of a skin care lotion containing Dexpanthenol, Glycerin and Citrate buffer on the exacerbation of allergic skin condition induced by birch pollen in atopic patients. Poster EADV (2011)
  
  
• J. Kühnl, L. Gonda, N. Peters, L. Kolbe, F. Rippke, S. Conzelmann, F. Stäb, G. Neufang: Protective efficacy in PLE by alpha-Glucosylrutin plus Licochalcone A. Poster EADV (2011)

• A. Mahns, M. Hong, J. Batzer, F. Staeb, T. Mann, W. Gerwat, C. Scherner, F. Rippke, L. Kolbe: Glycyrrhetinic acid significantly enhances the repair of UV-induced cyclobutane-pyrimidine-dimers in human skin. Poster EADV (2011)
  
  
• Maike Kuhlmann, Carsten Hartkopf, Rainer Wolber:  Assessment of local tolerability and wound healing properties of first aid dressings in sensitive, mature skin and diabetics in a suction blister wound model. Poster EADV (2011)
  
  
• Ruetze M, Dunckelmann K, Schade A, Reuschlein K, Mielke H, Weise JM, Gallinat S, Wenck H, Knott A. Damage at the root of cell renewal-UV sensitivity of human epidermal stem cells. J Dermatol Sci. 2011 Jun 30. [Epub ahead of print]
  
  
• Lutz V, Sattler M, Gallinat S, Wenck H, Poertner R, Fischer F. Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence. Skin Res Technol. 2011 May 12. [Epub ahead of print]
  
  
• Ito S, Nakanishi Y, Valenzuela RK, Brilliant MH, Kolbe L, Wakamatsu K. Usefulness of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin in various tissue samples: application to chemical analysis of human hair melanins. Pigment Cell Melanoma Res. 2011 Aug; 24(4):605-13

• Fischer F, Achterberg V, März A, Puschmann S, Rahn CD, Lutz V, Krüger A, Schwengler H, Jaspers S, Koop U, Blatt T, Wenck H, Gallinat S. Folic acid and creatine improve the firmness of human skin in vivo. J Cosmet Dermatol. 2011 Mar;10(1):15-23
  
  
• Scheede S, Herpens A, Burmeister F, Oltrogge B, Saenger K, Schmidt-Rose T, Schreiner V, Wenck H, Knieps T, Berlage T. Qualification of a new and precise automatic tool for the assessment of hair diameters in phototrichograms. Skin Res Technol. 2011 May;17(2):186-95
  
  
• Schmidt-Rose T, Braren S, Fölster H, Hillemann T, Oltrogge B, Philipp P, Weets G, Fey S. Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. Int J Cosmet Sci. 2011 Jun;33(3): 276-82
  
  
• Spörl F, Schellenberg K, Blatt T, Wenck H, Wittern KP, Schrader A, Kramer A. A circadian clock in HaCaT keratinocytes. J Invest Dermatol. 2011 Feb;131(2):338-48
  
  
• Reuter H, Spieker J, Gerlach S, Engels U, Pape W, Kolbe L, Schmucker R, Wenck H, Diembeck W, Wittern KP, Reisinger K, Schepky AG. In vitro detection of contact allergens: development of an optimized protocol using human peripheral blood monocyte-derived dendritic cells. Toxicol In Vitro. 2011 Feb;25(1):315-23
  
  
• Hildebrand J, Rütze M, Walz N, Gallinat S, Wenck H, Deppert W, Grundhoff A, Knott A. A comprehensive analysis of microRNA expression during human keratinocyte differentiation in vitro and in vivo. J Invest Dermatol. 2011 Jan;131(1):20-9
  
  
• Shosuke Ito, Yukiko Nakanishi, Robert K. Valenzuela, Muray H. Brilliant, Ludger Kolbe and Kazumasa Wakamatsu: Pigment Cell & Melanoma Research, DOI: 10.1111/j.1755-148x.2011.000864.x Volume 24, Issue 4, Pages 605-613
  
  
• Knott A., Drenckhan A., Reuschlein K., Lucius R., Stäb F., Wenck H., Gallinat S.: Decreased fibroblast contractile activity and reduced fibronectin expression are involved in skin photoaging, Poster FEBS 2011, Spetses
  
  
• J. Kühnl, L. Gonda, N. Peters, L. Kolbe, F. Stäb, G. Neufang: alpha-Glucosylrutin plus Licochalcone A: Enhanced Protective Efficacy in PLE, WCD 2011, Seoul
  
  
• M. Hong, J. Batzer, A. Mahns, T. Mann, W. Gerwat, C. Scherner, R. Wolber, F. Stäb, L. Kolbe: Modulation of DNA-Repair in UV-Irradiated Human Skin by Glycyrrhetinic Acid, WCD 2011, Seoul
  
  
• Meinke, M., Patzelt, A., Richter, H.,  Schanzer, S., Sterry, W., Filbry, A., Bohnsack, K., Rippke, F.,  Galecka, J., Fölster-Holst, R., Lademann, J.: Prevention of Follicular Penetration: Barrier-Enhancing Formulations against the Penetration of Pollen Allergens into Hair Follicles. Skin Pharmacol. Physiol. 2011;  24: 144-150
  

• S. Presto, F. Rippke, A. Schölermann, A. Filbry, W. Mei, F. L. Xiang:  The efficacy of Medical Skincare Products in Chinese Patients with Impure, Acne-prone Skin, WCD 2011, Seoul
  
  
• Martin A, Hellhammer J, Hero T, Max H, Schult J, Terstegen L. Effective prevention of stress-induced sweating and axillary malodour formation in teenagers. Int J Cosmet Sci. 2011 Feb;33(1):90-7
  
  
• Bilgram V, Biel S: Getting closer to the consumer – how Nivea co-creates new products. Marketing Review St. Gallen 1/2011, 34-40 (2011)