Studies & Publications 2016 – today

"Publish or perish" is a well-known phrase among scientists. This means that a major part of research is publicizing your own scientific findings within the scientific community. On the one hand, this serves to provide information about scientific progress, so that others can continue researching based on the latest findings. On the other hand, publishing work, particularly in scientific trade journals, serves to guarantee the quality of your own work and build a relationship with the scientific community. This is because trade journals only publish articles that have withstood a critical examination by recognized experts. For decades Beiersdorf has published its research findings in high-quality, accredited scientific trade magazines as well as in the form of lectures and posters at trade congresses, and as such, opens itself up to the critical opinion of the scientific community. The large number of publications since 1990 quite impressively demonstrates the weight Beiersdorf Research has in the world of global skin research.

2019

  • Marcheggiani F, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Knott A, Blatt T, Weise JM, Tiano L. Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. Aging (Albany NY) 2019, 11(9): 2565-2582
  • Mellem D, Fischer F, Jaspers S, Wenck H, Rübhausen M. Mitochondrial morphologies driven by energy-consuming cell sites in a spatially and time-resolved quality model. J. Comput. Biol. 2019, 26 (1): 76-85
  • Ito S, Kolbe L, Weets G, Wakamatsu K. Visible light accelerates the ultraviolet A-induced degradation of eumelanin and pheomelanin. Pigm. Cell Melanoma Res. 2019, 32 (3): 441-447
  • Kolbe L, Pissavini M, Tricaud C, Trullás Cabanas C, Dietrich E, Matts PJ. Anti-inflammatory / anti-oxidant activity of ingredients of sunscreen products? Implications for SPF. Int. J. Cosmet. Sci. 2019 May 14
  • Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L. Effective tyrosinase inhibition by thiamidol results in significant improvement of mild to moderate melasma. J. Invest. Dermatol. 2019 Feb 27
  • Rippke F, Berardesca E, Weber TM. pH-Wert und mikrobielle Infektionen. Karger Kompass Dermatol. 2019, 7: 62-67
  • Misery L, Santerre A, Batardière A, Hornez N, Nedelec AS, Le Caër F, Bourgeois P, Huet F, Neufang G. Real-life study of anti-itching effects of a cream containing menthoxypropanediol, a TRPM8 agonist, in atopic dermatitis patients. J. Eur. Acad. Dermatol. Venereol. 2019, 33 (2): e67-e69
  • Alépée N, Adriaens E, Abo T, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala À, Van Rompay AR, Verstraelen S, McNamee P. Development of a defined approach for eye irritation or serious eye damage for neat liquids based on cosmetics Europe analysis of in vitro RhCE and BCOP test methods. Toxicol. In Vitro 2019, 59:100-114
  • Alépée N, Adriaens E, Abo T, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala À, Van Rompay AR, Verstraelen S, McNamee P. Development of a defined approach for eye irritation or serious eye damage for liquids, neat and in dilution, based on cosmetics Europe analysis of in vitro STE and BCOP test methods. Toxicol. In Vitro 2019, 57: 154-163
  • Grégoire S, Cubberley R, Duplan H, Eilstein J, Hewitt NJ, Jacques-Jamin C, Genies C, Klaric M, Rothe H, Ellison C, Fernandez J, Schepky A. Use of a Simple in vitro test to assess loss of chemical due to volatility during an in vitro human skin absorption study. Skin Pharmacol. Physiol. 2019, 32 (3): 117-124
  • Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop. Regul. Toxicol. Pharmacol. 2019, 103: 63-72
  • Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C. Comparison of the metabolism of 10 chemicals in human and pig skin explants. J. Appl. Toxicol. 2019, 39(2): 385-397
  • Schepky A, Coecke A, Jacques Jamin C, Kuehnl J. In vitro static and dynamic skin metabolism methods and strategies to address the safety assessment of topically applied chemicals. Presentation, SOT, San Antonio, USA, March 11-15, 2019
  • Ellison C. Internal TTC: Where are we today? What is possible for the near future? Presentation, SCCS Workshop Brussels, Belgium, February 27, 2019
  • Schepky A, Bernau M, Duplan H, Eilstein J, Ellison C, Fabian E, Genies C, Grégoire S, Hewitt N, Jacques-Jamin C, Lester L, Salhi S, Sorrell I, Klaric M. Cosmetics Europe’s non-animal strategy: toxicokinetics for systemic toxicity assessment. Presentation, BTS, Cambridge, UK, April 15-17, 2019
  • Altgilbers S, Holtzmann U, Rippke F, Filbry A, Conzelmann S, Weber TM, Vietzke JP, Burkhardt T, Roggenkamp D, Groenniger, E. Enhancement of skin barrier function on a cellular and phenotypic level: Integrative effects of a novel multi-functional moisturizer. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Zöllner D, Filbry A, Scherdin U, Harbig S, Rippke F, Schneider G. Busting a modern myth: Ethanol at a concentration of 10% is very well tolerated in skin care formulations even by sensitive skin sufferers – Results of 6 independent in vivo studies. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Keyhanian S, Warnke K, Buerger A, Klensang K, De Kleijn S. Efficacy of a cosmetic formulation containing Licochalcone A, Salicylic Acid, Decanediol and sebum-regulating technology with L-Carnitine in subjects with acne lesions. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Van Geloven A, Nizet J, Koop U, Warnke K, Conzelmann S. Formulations containing a combination of Magnolia Bark Extract, Oligopeptides and Hyaluronic Acid significantly reduce jowling in ageing skin. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Van Geloven A, Djamil J, Fürstenau M, Harbig S, Warnke K. Formulations containing a combination of AHA, Saponin and Hyaluronic Acid significantly improve blemishes and wrinkles in subjects with ageing skin and acne tarda. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Mann T, Eggers K, Kolbe L. Effective photoprotection against UV- and VIS-induced oxidative stress by active ingredients requires Nrf2-induction. Poster, 24th World Congress of Dermatology, Milano, Italy, 2019
  • Kuhlmann M, Wigger-Alberti W, v. Mackensen Y, Ebbinghaus M, Williams R, Krause-Kyora F, Wolber R. Wound healing characteristics of a novel wound healing ointment in an abrasive wound model: A randomised, intra-individual clinical investigation. Wound Med. 2019, 24: 24-32

2018

  • Mann T, Scherner C, Röhm K-H, Kolbe L. Structure-activity relationships of thiazolyl resorcinols, potent and selective inhibitors of human tyrosinase. Int. J. Mol. Sci. 2018, 19: 690
  • Mann T, Gerwat W, Batzer J, Eggers K, Scherner C, Wenck H, Stäb F, Hearing VJ, Röhm K-H, Kolbe L. Inhibition of human tyrosinase requires molecular motifs distinctively different from mushroom tyrosinase. J. Invest. Dermatol. 2018, 138: 1601-1608
  • Mann T, Gerwat W, Wenck H, Roehm KH, Kolbe L. Isobutylamido thiazolyl resorcinol – a highly effective inhibitor of human tyrosinase. Poster, 27th EADV Congress, Paris, France 2018
  • Roggenkamp D, Riedel J, Muhr G-M, Warnke K, Kolbe L, Filbry A. Efficacy of skin care formulations with Thiamidol in reducing facial hyperpigmentation. Poster, 27th EADV Congress, Paris, France 2018
  • Eggers K, Mann T, Kolbe L. Antioxidants for effective photoprotection against high energy visible light. Poster, 27th EADV Congress, Paris, France 2018
  • Ladewig S, Mann T, Kolbe L, Weise J. Licochalcone A protects from reactive oxygen species and matrix metalloproteinase-1 expression induced by high-energy visiblelight irradiation in vitro. Poster, 27th EADV Congress, Paris, France 2018
  • Batzer J, Eggers K, Kolbe L, Weise J. Assessment of hazard potential of high-energy visible light from electronic devices for the skin. Poster, 27th EADV Congress, Paris, France 2018
  • Pissavini M, Tricaud C, Wiener G, Lauer A, Contier M, Kolbe L, Trullas Cabanas C, Boyer F, Nollent V, Meredith E, Dietrich E, Matts PJ. Validation of an in vitro sun protection factor (SPF) method in blinded ring-testing. Int. J. Cosmet. Sci. 2018, 40, 263–268
  • Bielfeldt S, Klette E, Rohr M, Herzog B, Grumelard J, Hanay C, Heinrich U, Hansen P, Kockotth D, Lademann J, Mendrok-Edinger C, Peters,k, Rudolph T, Schläger T, Tronnier H,  Wiechers S, Zastrow L, Pflücker F. Multicenter methodology comparison of the FDA and ISO standard for measurement of in vitro UVA protection of sunscreen products. J. Photochem. Photobiol. B: Biol. 2018, 189: 185-192
  • Rodríguez-Paredes M, Bormann F, Raddatz G, Gutekunst J, Lucena-Porcel C, Köhler F,  Wurzer E, Schmidt K, Gallinat S, Wenck H, Röwert-Huber J, Denisova E, Feuerbach L,  Park J, Brors B, Herpel E, Nindl I, Hofmann TG, Winnefeld M, Lyko F. Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nature Commun. 2018, 9: 577
  • Madsen JGS, Rauch A, Van Hauwaert EL, Schmidt SF, Winnefeld M, Mandrup S. Integrated analysis of motif activity and gene expression changes of transcription factors. Genome Res. 2018, 28: 243–255
  • Bobrov E, Georgievskaya A, Kiselev K, Sevastopolsky A, Zhavoronkov A, Gurov S, Rudakov K, del Pilar Bonilla Tobar M, Jaspers S, Clemann C. PhotoAgeClock: deep learning algorithms for development of noninvasive visual biomarkers of aging. Aging 2018, 10 (11): 3249-3259
  • Gan J, Wilbert A, Thormählen T, Drescher P, Hagens R. Multi-view photometric stereo using surface deformation. Visual Computer 2018, 34 (11): 1551-1561
  • Blatt T.New results: Q10 and creatine. Cossma 2018: 15-18
  • Vogelsang A, Krüger A, Sperling G, Batzer J, Burkhardt T, Grönniger E, Wenck H, Blatt T, Weise JM. Enhancing the anti-aging effects of Coenzyme Q10 by antioxidants and energy metabolites. Poster, 9th Conference of the International Coenzyme Q10 Association, New York, USA 2018.
  • Huet F, Bataille A, Cheret J, Neufang G, De Kleijn S, Roggenkamp D, Lebonvallet N,  Misery L, Christelle I. Étude in vitro de l’effet du menthoxypropanédiol sur le prurit au cours de la dermatite atopique : rôle du récepteur TRPM-8 (abstr.). Ann. Derm. Venereol. 2018, 145 (12) Suppl.: S122
  • Worthmann A, Sperling G, Holtzmann U, Rippke F, Grönniger E. Polidocanol inhibits the release of thymic stromal lymphopoietin (TSLP) in human keratinocytes in vitro. Poster, 27th EADV Congress, Paris, France 2018
  • Rippke F, Berardesca E, Weber TM. pH and microbial infections. Curr. Probl. Dermatol. 2018, 54: 87-94
  • Welge V, Sulzberger M, Worthmann A, Holtzmann U, Sperling G, Rippke F, Filbry A, Kuhn A, Gallinger J, Grönniger E. A novel body moisturizer with effective pH buffer system and Dexpanthenol protects the skin against environmental triggers in vitro, ex vivo and in vivo. Poster, 27th EADV Congress, Paris, France 2018
  • Angelova-Fischer I, Rippke F, Richter D, Filbry A, Arrowitz C, Weber T, Fischer T, Zillikens D. Stand-alone emollient treatment reduces flares after discontinuation of topical steroid treatment in atopic dermatitis: a double-blind, randomized, vehicle-controlled, left-right comparison study. Acta Derm. Venereol. 2018, 98: 517-523
  • Weber TM, Arrowitz CE, Jiang LI, Qian K, Filbry A. Efficacy of an ointment body spray to improve the appearance of dry, ashy skin and alleviate moderate to severe dryness on the heel. Poster, Fall Clinical Dermatology Conference, Las Vegas, USA 2018
  • Weber TM, Arrowitz CE, Scherdin U, Schoelermann AM, Filbry A. A moisturizing spray ointment to help alleviate dry skin symptoms associated with atopic eczema, psoriasis, and xerosis. Poster, Fall Clinical Dermatology Conference, Las Vegas, USA 2018
  • Wilm A, Kühnl J, Kirchmair J. Computational approaches for skin sensitization prediction. Crit. Rev. Toxicol. 2018, 48 (9): 738-760
  • Desprez B, Dent M, Keller D, Klaric M, Ouédraogo G, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt N, Jacques-Jamin C, Lange D, Roe A, Rothe H, Blaauboer B, Schepky A, Mahony C. A strategy for systemic toxicity assessment based on non-animal approaches: The cosmetic Europe Long Range Science Strategy programme. Toxicol. in Vitro 2018, 50: 137-146
  • Hoffmann S, Kleinstreuer N, Alepee N, Allen D, Apie AM, Ashikaga T, Clouet E, Cluzel M,  Desprez B, Gellatly N, Goebel C, Kern PS, Klaric M, Kühnl J, Lalko JF, Martinozzi-Teissier S, Mewes K, Miyazawa M, Parakhia R, van Vliet E, Zang Q, Petersohn D. Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database. Crit. Rev. Toxicol. 2018, 48 (5): 344-358
  • Kleinstreuer NC, Hoffmann S, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Desprez B, Gellatly N, Göbel C, Kern PS, Klaric M, Kühnl J, Martinozzi-Teissier S, Mewes K, Miyazawa M, Strickland J, van Vliet E, Zang Q, Petersohn D. Non-animal methods to predict skin sensitization (II): an assessment of defined approaches. Crit. Rev. Toxicol. 2018, 48 (5): 359-374
  • van Vliet E, Kühnl J, Goebel C, Martinozzi-Teissier S, Alépée N, Ashikaga T, Blömeke B,  Del Bufalo A, Cluzel M, Corsini E, Delrue N, Desprez B, Gellatly N, Giese C, Gribaldo L,  Hoffmann S, Klaric M, Maillere B, Naisbitt D, Pallardy M, Vocanson M, Petersohn D. State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop. Altex 2018, 35 (2): 178-192
  • Klaric M, Bernau M, Duplan H, Eilstein J, Ellison C, Fabian E, Genies C, Grégoire S, Hewitt N, Jacques-Jamin C, Lester C, Salhi S, Sorrell I, Schepky A. Cosmetics Europe’s non-animal strategy: toxicokinetics for systemic toxicity assessment. Oral presentation, GMP Conference, Paris, France 2018
  • Kühnl J, Maschmeyer I, Brandmair K, Tao TP, Gerlach S, Müller-Vieira U, Duplan H, Eilstein J, Ellison C, Grégoire S; Jacques-Jamin C, Klaric M, Lange D; Lester C, Salhi S, Sorrell I0, Marx U, Schepky A, Hewitt N. Characterization of chemical metabolism in skin and liver models over extended and repeated exposure in a multi organ chip device. Oral presentation, EUSAAT Conference, Linz, Austria 2018
  • Klaric M, Cubberley R, Sorrell I, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt N, Jacques-Jamin C, Lange D, Lester C, Rothe H, Salhi S, Schepky A. Evaluation of 6 in silico skin penetration models to predict the in vitro cutaneous distribution of 25 chemicals. Oral presentation, Eurotox Conference, Brussels, Belgium 2018
  • Martina Klaric & Cosmetics Europe Task Force ADME. In silico modelling of skin penetration. Oral presentation, AlterTox Meeting, Brussels, Belgium 2018
  • Schepky A, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt N, Jacques-Jamin C, Lange D, Roe A, Rothe H, Salhi S, Klaric M. Cosmetics Europe evaluation of 5 in silico skin penetration models. Poster, 57th SOT Conference, San Antonio, USA 2018
  • Obringer C, Tankersley K, Hewitt N, Schepky A, Lange D, Klaric M, Eilstein J, Grégoire S, Duplan H, Jacques-Jamin C, Cubberley R, Salhi S, Rothe H, Roe A, Ellison C. Partition and diffusion coefficient determinations in isolated human skin layers for in silico skin penetration modeling. Poster, 57th SOT Conference, San Antonio, USA 2018
  • Efremenko AY, Nicolas CI, Hack E, Ellison C, Mansouri K, McMullen PD, Klaric M, Hewitt N, Clewell HJ. Evaluation of platforms used for fit-for-purpose PBPK modeling in chemical safety assessment. Poster, 57th SOT Conference, San Antonio, USA 2018
  • Ouédraogo G, Van der burg Bart, Bury D, Eilstein J, Grégoire S, Mahony C, Tozer S, Roe A, Dent M, Nicol B, Cubberley R, Duplan H, Jacques C, Ellison C, Lange D, Schepky A, Rothe H, Keller D , Hewitt N, Klaric M, Desprez B. Exposure-led safety assessment framework for systemic toxicity: initial case studies from Cosmetics Europe. Poster, 57th SOT Conference, San Antonio, USA 2018
  • ScitoVation & Cosmetics Europe Task Force ADME. Incorporating TK data and tools to support regulatory decision making – from the perspectives of cosmetic industry” OR “Using TK data and tools to support regulatory decision making – from the perspectives of cosmetic industry. Poster, Eurotox Conference, Brussels, Belgium 2018
  • Kühnl J, Maschmeyer I, Brandmair K, Tao TP, Gerlach S, Müller-Vieira U, Duplan H, Eilstein J, Ellison C, Grégoire S, Jacques-Jamin C, Klaric M, Lange D; Lester C, Salhi S, Sorrell I, Marx U, Schepky A, Hewitt N. Characterization of chemical metabolism in a multi organ chip device integrating skin and liver models. Poster, 20th ESTIV Conference, Berlin, FRG 2018
  • Schwarz K, Pappa G, Miertsch H, Scheel J, Koch W. A methodology for the assessment of inhalation exposure to aluminium from antiperspirant sprays. Arch. Toxicol. 2018, 92:1383-1392
  • Steiling W, Almeida JF, Assaf Vandecasteele H, Gilpin S, Kawamoto T, O’Keeffe L, Pappa G, Rettinger K, Rothe H, Bowden AM. Principles for the safety evaluation of cosmetic powders. Toxicol. Lett. 2018, 207: 8-18
  • Mastrangeli M, Millet S, ORCHID partners (Kuehnl J), van den Eijnden-van Raaij J. Organ-on-Chip In Development: Towards a roadmap for Organs-on-Chip. Preprints 2018

2017

  • Kessler L, Gehrke S, Winnefeld M, Huber B, Hoch E, Walter T, Wyrwa R, Schnabelrauch M, Schmidt M, Kückelhaus M, Lehnhardt M, Hirsch T, Jacobsen F Methacrylated gelatin/hyaluronan-based hydrogels for soft tissue engineering · J Tissue Engin 2017, 21 (8): 1-14 
  • Kuehne A, Hildebrand J, Soehle J, Wenck H, Terstegen L, Gallinat S, Knott A, Winnefeld M, Zamboni N An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo · BMC Genomics 2017, 18 (1): 169 
  • Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M Identification of miR-126 as a new regulator of skin ageing · Exp Dermatol 2017, 26 (3): 284-286  
  • Behm P, Hashemi M, Hoppe S, Wessel S, Hagens R, Jaspers S, Wenck H, Rübhausen M Confocal spectroscopic imaging measurements of depth dependent hydration dynamics of human skin in-vivo. AIP Advances 2017, 7: 115004 
  • Schulze C, Jaspers S Measuring skin cell stiffness. In: Measuring the skin, Agache (ed) · Springer International Publishing AG, Cham, Switzerland 2017: 1511-1521 
  • Mellem D, Sattler M, Pagel-Wolff S, Jaspers S, Wenck H, Rübhausen MA, Fischer F Fragmentation of the mitochondrial network in skin in vivo · PLoS ONE 2017, 12 (6): e0174469 
  • Trautmann M, Wendel V, Prinz D, Primmel B, Willging G, Nagorsen E, Suckert A, Gehm S, Brandt M, Ballay P, Godde B Not only age but also tactile perception influences the preference for cosmetic creams applied to the forearm · Int J Cosmet Sci 2017, 39: 344-350 
  • Peters EMJ, Müller Y, Snaga W, Fliege H, Reißhauer A, Schmidt-Rose T, Max H, Schweiger D, Rose M, Kruse J Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress · PLoS ONE 2017, 12 (4): e0175904 
  • Traupe B, Fölster H, Max H, Schulz J Effective axillar malodour reduction by polyquaternium-16 containing deodorants · Int J Cosmet Sci 2017, 39: 141-148 
  • Choi W, Jin L, Smuda C, Batzer J, Hearing VJ, Kolbe L Molecular and histological characterization of age spots · Exp Dermatol 2017, 26: 242-248 
  • Ito S, Kolbe L Tyrosine peptides provide a color palette upon tyrosinase oxidation: nanosize does matter · Pigment Cell Melanoma Res 2017, 30 (1): 4-5 
  • Mann T, Gerwat W, Wenck H, Röhm K-H, Kolbe L Isobutylamido thiazolyl resorcinol a new powerful inhibitor of human tyrosinase · Pigment Cell Melanoma Res 2017, 30: e85-e86 
  • Fürtjes T, Weiss KT, Filbry A, Rippke F, Schreml S Impact of a pH5 oil-in-water emulsion on skin surface pH · Skin Pharmacol Physiol 2017, 30: 292-297 
  • Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells · Exp Dermatol 2017, 26 (1): 44-50 
  • Jovanovic Z, Schornstein T, Sutor A, Neufang G, Hagens R Conventional sunscreen application does not lead to sufficient body coverage · Int J Cosmet Sci 2017, 39: 550-55 
  • Ständer S, Blome C, Anastasiadou Z, Zeidler C, Jung KA, Tsianakas A, Neufang G, Augustin M Dynamic pruritus score: Evaluation of the validity and reliability of a new instrument to assess the course of pruritus · Acta Derm Venereol 2017, 97: 230-234 
  • Ständer S, Augustin M, Roggenkamp D, Blome C, Heitkemper T, Worthmann AC, Neufang G Novel TRPM8 agonist cooling compound against chronic itch: results from a randomized, double-blind, controlled, pilot study in dry skin · JEADV 2017, 31: 1064-1068 
  • Meinke M, Richter H, Buerger A, Kohlhase S, Burkhardt T, Rippke F, Patzelt A, Lademann J Follicular penetration of licochalcone A and salicylic acid investigated by differential stripping · Poster P0049, 26th EADV Congress, Geneva 2017 
  • Keyhanian S, Schoelermann AM, Warnke K, Buerger A, Neufang G Beneficial role of adjunctive skin care for patients receiving acne medication · Poster P0057, 26th EADV Congress, Geneva 2017 
  • Keyhanian S, Buerger A , Morgenroth-Ehrich S , Warnke K, Neufang G, Klensang K Efficacy of a new cosmetic formulation containing 10% Hydroxy Complex and licochalcone A in subjects with acne lesions · Poster P0058, 26th EADV Congress, Geneva 2017 
  • Jovanovic Z, Roggenkamp D, Neufang G, Haus A Efficacy and skin tolerability of a skin care regimen with licochalcone A and 4-t-butylcyclohexanol as preparation for and post-treatment of facial erythema with laser · Poster P1305, 26th EADV Congress, Geneva 2017 
  • Krueger A, Filbry A, Mielke H, Gallinat S, Roggenkamp D, Weise J The active ingredient combination of glycine saponin, hyaluronic acid and urea is beneficial for anti-aging efficacy and moisturization in vitro and in vivo · Poster P0490, 26th EADV Congress, Geneva 2017 
  • Jovanovic Z, Sutor A, Hagens R, Schornstein T, Roggenkamp D, Neufang G Common sunscreen application routine does not provide sufficient body coverage · Poster P1623, 26th EADV Congress, Geneva 2017 
  • Welge V, Sulzberger M, Klensang K, Rippke F, Filbry A, Harbig S, Roggenkamp D, Grönniger E The protective shielding effect of a novel body moisturizer for sensitive skin in vitro and in vivo · Poster P1988, 26th EADV Congress, Geneva 2017 
  • Srour J, Bengel J, Linden T, Jovanovic Z, Roggenkamp D, Reinholz M, Rothenberger C, Neufang G, Wollenberg A Skin compatibility and efficacy of a cosmetic skin care regimen with 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis · Poster P2117, 26th EADV Congress, Geneva 2017 
  • Rothe H, Obringer C, Manwaring J, Avci C, Wargniez C, Eilstein J, Hewitt N, Cubberley R, Duplan H, Lange D, Jacques-Jamin C, Klaric M, Schepky A, Gregoire S Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum · J Appl Toxicol 2017, 37: 806-81 
  • Barroso J, Pfannenbecker U, Adriaens E, Alépée N, Cluzel M, De Smedt A, Hibatallah J, Klaric M, Mewes KR, Millet M, Templier M, McNamee P Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD) · Arch Toxicol. 2017, 91 (2): 521-54 
  • Schwarz K, Pappa G, Miertsch H, Scheel J, Koch W A methodology for the assessment of inhalation exposure to aluminium from antiperspirant sprays · Arch Toxicol 2017, in press 
  • Jacques-Jamin C, Duplan H, Rothe H, Vaillant O, Eilstein J, Gregoire S, Cubberley R, Lange D, Ellison C, Klaric M, Hewitt N, Schepky A Comparison of the skin penetration of 3 metabolically stable chemicals using fresh and frozen human skin · Skin Pharmacol Physiol 2017, 30: 234-245
  • Schepky A, Reuter H, Kühnl J, Aeby P  Human peripheral blood monocyte derived dendritic cells assay for the detection and characterization of sensitizers · In: Eskes C, van Vliet E, Maibach H (eds) Alternatives for dermal toxicity testing Springer, Cham 2017: 331-345 
  • Van Vliet E, Kühnl J, Goebel C, Martinozzi-Teissier S, Alepee N, Ashikaga T, Blömeke B, del Bufalo A, Cluzel M, Corsini E, Delrue N, Desprez B, Gellatly N, Giese C, Gribaldo L, Hoffmann S, Klaric M, Maillere B, Naisbitt D, Pallardy M, Vocanson M, Petersohn D Consensus report: State-of-the-art and new options to assess T cell activation by skin sensitizers: Cosmetics Europe Workshop · ALTEX Online first, October 2, 2017 
  • Petry T, Bury D, Fautz R, Hauser M, Huber B, Markowetz A, Mishra S, Rettinger K, Schuh W, Teichert T Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications · Toxicol Letters 2017, 280: 70-78 
  • Pfannenbecker U, Wenck H, Schepky A Photo-safety assessment for cosmetics based on in vitro tests · Toxicol Letters 2017, 280S: S17-S18   
  • Gregoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, Hewitt N, Jacques-Jamin C, Lange D, Klaric M, Rothe H, Schepky A, Roe A Impact of cutaneous bioavailability in local skin toxicity: Preliminary results from cosmetics Europe skin bioavailability and metabolism task force · Toxicol Letters 2017, 280S: S44
  • Grégoire S, Cubberley R, Duplan H, Eilstein J, Lange D, Hewitt N, Jacques-Jamin C, Klaric M, Rothe H, Ellison C, Vaillant O, Schepky A Solvent solubility testing of cosmetics-relevant chemicals: Methodology and correlation of water solubility to in silico predictions · J Solution Chem 2017, 46: 1349 
  • Maschmeyer I, Lorenz A, Bauer S, Ramme A, Rings T, Kuehnl J, Marx U State-of-the-art of the assessment of ADME using multiple organs on a chip · Toxicology Letters 2017, 280: S34 
  • Lange D, Jaques-Jamin C, Eilstein J, Duplan H, Genies C, Gregoire S, Cubberley R, Ellison C, Klaric M, Roe A, Rothe H, Salhi S, Hewitt N, Schepky A Comparison of in vitro metabolism models for cosmetics relevant prediction of skin absorption and toxicity · ALTEX Proc 2017, 6 (1): 24 
  • Schepky A , Maschmeyer I, Rings T, Huebner J, Gerlach S, Marx U, Kuehnl J Retinoic acid as an example for a toxicokinetic study in a multiorgan chip comprising EpiDerm skin models and liver organoids · ALTEX Proc 2017, 6 (1): 36    
  • Schepky A, Cubberley R, Duplan H, Eilstein J,  Ellison C,  Gregoire S, Hewitt N, Jaques-Jamin C, Lange D, Roe A, Rothe H, Klaric M Better understanding of bioavailability of cosmetic ingredients: Results from Cosmetics Europe skin bioavailability project · ALTEX Proc 2017, 6 (1): 39 
  • Alépée N, Adriaens E, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala A, McNamee P Testing strategies for UN GHS classification for serious eye damage/eye irritation of chemicals: Cosmetics Europe analysis · ALTEX Proc 2017, 6 (1): 40
  • Desprez B, Adriaens E, Alépée N, Bagley D, Hibatallah J, Mewes KR, Pfannenbecker U, Sala A, McNamee P The importance of understanding physico-chemical properties of chemicals in the evaluation of serious eye damage/eye irritation: Cosmetic Europe analysis · ALTEX Proc 2017, 6 (1): 41 
  • McNamee P, Alépée N, Adriaens E, Bagley D, Desprez B, Hibatallah J, Mewes K, Pfannenbecker U, Sala A Cosmetics Europe eye programme: Relevance to integrated approaches on testing and assessment for eye hazard ALTEX Proc 2017, 6 (1): 43 
  • Klaric M, Alépée N, Allen D, Ashikaga T, Casey W, Clouet E, Cluzel M, Del Bufalo A,  Gellatly N, Goebel C, Hoffmann S, Kern P, Kleinstreuer N, Kuehnl J, Mewes K, Miyazawa M, Petersohn D, Strickland J, Van Vliet E, Zang D Cosmetics Europe assessment of non-animal approaches for predicting skin sensitization · ALTEX Proc 2017, 6 (1): 94 
  • Desprez B, Reisinger K, Fieblinger D, Heppenheimer A, Kuehnl J, Kreutz J, Liebsch M, Luch A, Maul K, Poth A, Strauch P, Voelkner W, Wolf T, Pirow R The HET-MN (Hen’s Egg Test for Micronucleus-Induction): Promising pre-validation study · ALTEX Proc 2017, 6 (1): 120 
  • Fautz R, Desprez B, Hoffmann S, Hewitt N, Fowler P, Reisinger K, Kuehnl J, Ouedraogo G, Kenny J, Pfuhler S Use of newly validated 3D reconstructed human skin genotoxicity assays and hens egg test micronucleus in testing strategies improve predictions in safety assessments of cosmetic ingredients · ALTEX Proc 2017, 6 (1): 125 292
  • Desprez B, Klaric M, Taalman R, Schepky A, Blaauboer B Cosmetics Europe long range science strategy for non-animal-based safety assessments · ALTEX Proc 2017, 6 (1): 202
  • Lange D, Herberz I, Mikolon J, Akhiani M, Wenck H, Schepky A Impact of stripping technique in skin penetration studies on rate of dermal absorption · ALTEX Proc 2017, 6 (1): 225
  • Mellem D, Sattler M, Pagel-Wolff S, Jaspers S, Wenck H, Ruebhausen MA, Fischer F. Fragmentation of the mitochondrial network in skin in vivo. PLoS ONE 2017; 12(6): e0174469.  
  • Clemann S., Beauty AI: experiments and visions in skin care, lecture on 2nd Korea Future Forum, Seoul, Korea  
  • Ito S, Kolbe L. Tyrosine peptides provide a color palette upon tyrosinase oxidation: nanosize does matter.Pigment Cell Melanoma Res. 2017; 30(1):4-5  
  • Rothe H, Obringer C, Manwaring J, Avci C, Wargniez W, Eilstein J, Hewitt N, Cubberley R, Duplan H, Lange D, Jacques-Jamin C, Klaric M, Schepky A, Grégoire S. Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum. J Appl Toxicol. 2017; 37(7):806-816  
  • Trautmann M, Wendel V, Prinz D, Primmel B, Willging G, Nagorsen E, Suckert A, Gehm S, Brandt M, Ballay P, Godde B. Not only age but also tactile perception influences the preference for cosmetic creams applied to the forearm. Int J Cosmet Sci. 2017; 39(3):344-350  
  • Peters EMJ, Müller Y, Snaga W, Fliege H, Reißhauer A, Schmidt-Rose T, Max H, Schweiger D, Rose M, Kruse J. Hair and stress: A pilot study of hair and cytokine balance alteration in healthy young women under major exam stress. PLoS ONE. 2017; 12(4): e0175904  
  • Traupe B, Fölster H, Max H, Schulz J. Effective axillary malodour reduction by polyquaternium-16-containing deodorants. Int J Cosmet Sci. 2017; 39(2):141-148  
  • Choi W, Yin L, Smuda C, Batzer J, Hearing VJ, Kolbe L. Molecular and histological characterization of age spots. Exp Dermatol. 2017; 26(3):242-248  
  • Fiedler J, Grönniger E, Pfanne A, Brönneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M. Identification of miR-126 as a new regulator of skin ageing. Exp Dermatol. 2017; 26(3):284-286  
  • Kuehne A, Hildebrand J, Soehle J, Wenck H, Terstegen L, Gallinat S, Knott A, Winnefeld M, Zamboni N. An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo. BMC Genomics. 2017; 18(1):169  
  • Barroso J, Pfannenbecker U, Adriaens E, Alépée N, Cluzel M, De Smedt A, Hibatallah J, Klaric M, Mewes KR, Millet M, Templier M, McNamee P. Cosmetics Europe compilation of historical serious eye damage/eye irritation in vivo data analysed by drivers of classification to support the selection of chemicals for development and evaluation of alternative methods/strategies: the Draize eye test Reference Database (DRD). Arch Toxicol. 2017; 91(2):521-547  
  • Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D. Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells. Exp Dermatol. 2017; 26(1):44-50  
  • Schulze C, Jaspers S. Measuring Skin Cell Stiffness. In: Measuring the Skin, Agache (ed), Springer International Publishing AG, Cham, Switzerland pp.1511-1521, 2017

2016

  • Kolbe L. Biological Cell Protection by Natural Compounds, a Second Line of Defense Against Solar Radiation in: Skin Stress Reponse Pathways, Wondrak G (ed), Springer International Publishing AG, Cham, Switzerland, pp 361-378, 2016
  • Roggenkamp D, Worthmann AC, Sulzberger M, Wenck H, Stäb F, Neufang G. Menthoxypropanediol inhibits nerve growth factor-induced nerve fibre sprouting in coculture models of sensory neurons and skin cells. Exp Dermatol. 2016; 25(10):824-6
  • Schweiger D, Hoff A, Scheede S, Fischer F, Tilsner J, Lüttke J, Neumann Y, Hagens R. Towards a body hair atlas of women of caucasian ethnicity. Int J Cosmet Sci. 2016;  38(4):409-20
  • Sulzberger M, Fölster H, Sattler M, Rippke F, Grönniger E. Inhibition of Propionibacterium acnes associated biofilm formation by Decanediol. J Dermatol Sci. 2016; 83(2):159-61
  • Huber B, Link A, Linke K, Gehrke SA, Winnefeld M, Kluger PJ. Integration of Mature Adipocytes to Build-Up a Functional Three-Layered Full-Skin Equivalent. Tissue Eng Part C Methods. 2016; 22(8):756-64
  • Gerstel D, Jacques-Jamin C, Schepky A, Cubberley R, Eilstein J, Grégoire S, Hewitt N, Klaric M, Rothe H, Duplan H. Comparison of protocols for measuring cosmetic ingredient distribution in human and pig skin. Toxicol In Vitro. 2016; 34:153-60
  • Bormann F, Rodríguez-Paredes M, Hagemann S, Manchanda H, Kristof B, Gutekunst J, Raddatz G, Haas R, Terstegen L, Wenck H, Kaderali L, Winnefeld M, Lyko F. Reduced DNA methylation patterning and transcriptional connectivity define human skin aging. Aging Cell. 2016; 15(3):563-71
  • Batzer J, Bleckmann A, Lerg H, Schwanke F, Schläger T. The 'Dispersal Rate' - a product dependent characteristic to predict the reliability of the calibrated in vitro SPF on WW5 plates. Int J Cosmet Sci. 2016; 38(3):294-304
  • Alépée N, Hibatallah J, Klaric M, Mewes KR, Pfannenbecker U, McNamee P. Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkin™ using HPLC/UPLC-spectrophotometry in the MTT-reduction assay. Toxicol In Vitro. 2016; 33:105-17
  • Kwiatkowski M, Wurlitzer M, Krutilin A, Kiani P, Nimer R, Omidi M, Mannaa A, Bussmann T, Bartkowiak K, Kruber S, Uschold S, Steffen P, Lübberstedt J, Küpker N, Petersen H, Knecht R, Hansen NO, Zarrine-Afsar A, Robertson WD, Miller RJD, Schlüter H. Homogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization. J Proteomics. 2016; 16;134:193-202
  • Marx U, Andersson TB, Bahinski A, Beilmann M, Beken S, Cassee FR, Cirit M, Daneshian M, Fitzpatrick S, Frey O, Gaertner C, Giese C, Griffith L, Hartung T, Heringa MB, Hoeng J, de Jong WH, Kojima H, Kuehnl J, Leist M, Luch A, Maschmeyer I, Sakharov D, Sips AJ, Steger-Hartmann T, Tagle DA, Tonevitsky A, Tralau T, Tsyb S, van de Stolpe A, Vandebriel R, Vulto P, Wang J, Wiest J, Rodenburg M, Roth A:  Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. ALTEX. 2016; 33(3): 272-321.
  • Roggenkamp D, Koop U, Filbry A, Keyhanian S, de Kleijn S, Conzelmann S, Neufang G. Vehicle-controlled treatment of xerosis with a topical formulation containing natural moisturizing factors and lipids. Poster P2264, 25th EADV Congress, Vienna 2016
  • Altgilbers S, Holtzmann U, Worthmann A-C, Neufang G, Rippke F, Grönniger E. The antioxidant Silymarin S protects and activates dermal microcapillaries in vitro. Poster P0498, 25th EADV Congress, Vienna 2016
  • Neufang G, Rümmelein B, Sögding-Beck K, Reljić D, Demschik G, Rigoni C, Cantú A, Jovanović Z. Dermocosmetic approach in the management of hypersensitive skin - Results of an international study involving 647 patients. Poster P0490, 25th EADV Congress, Vienna 2016
  • Van Geloven A, Klensang K, Djamil J, Neufang G, Warnke K. Formulations containing Silymarin S and Arctiin significantly improve the elasticity and microvascular structure of ageing skin. Poster P2194, 25th EADV Congress, Vienna 2016
  • Bormann F, Rodríguez-Paredes M, Hagemann S, Manchanda H, Kristof B, Gutekunst J, Raddatz G, Haas R, Terstegen L, Wenck H, Kaderali L, Winnefeld M, Lyko F. Reduced DNA methylation patterning and transcriptional connectivity define human skin aging. Aging Cell. 2016, 15(3): 563-71.
  • Meinke MC, Schanzer S, Richter H, Rippke F, Filbry A, Bohnsack K, Patzelt A, Lademann J. Prevention of cutaneous penetration and CD1c+ uptake of pollen allergens by a barrier-enhancing formulation. Skin Pharmacol Physiol 2016, 29: 71-75
  • Klaric M, Pfannenbecker U, Adriaens E, Alepee N, Barroso J, Hibatallah J, Mewes KR, McNamee P. Critical Review of the UN GHS Decision Criteria for Chemicals Causing Irreversible Effects on the Eye/Serious Damage to the Eye: Cosmetics Europe Analysis. 55th Annual Meeting of the Society of Toxicology, New Orleans 2016 (Poster).
  • Alépée N, Hibatallah J, Klaric M, Mewes KR, Pfannenbecker U, McNamee P. Assessment of cosmetic ingredients in the in vitro reconstructed human epidermis test method EpiSkin™ using HPLC/UPLC-spectrophotometry in the MTT-reduction assay. Toxicology in Vitro 33, 105–117, 2016.
  • Darvin ME,  Schanzer S, Lademann J, Tesch M, Buerger A, Rippke F, Meinke MC. Protective efficacy of a licochalcone A containing sunscreen in the high energy visible spectral range in vivo (abstr.). Exp. Dermatol. 2016, 25: E32
  • Darvin ME,  Schanzer S, Lademann J, Tesch M, Buerger A, Rippke F, Meinke MC. Licochalcone A containing sunscreen protects the skin from carotenoid depletion induced by irradiation with high energy visible light - Results of a double-blind, vehicle-controlled in vivo study. Poster P1795, 25th EADV Congress, Vienna 2016
  • Sulzberger M, Worthmann A-C, Holtzmann U, Buck B, Jung KA, Schoelermann AM, Rippke F, Stäb F, Wenck H, Neufang G, Grönniger E. Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A. JEADV 2016, 30 (Suppl. 1): 9-17
  • Schoelermann AM, Jung KA, Buck B, Groenniger E, Conzelmann S. Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin. JEADV 2016, 30 (Suppl. 1): 18-20
  • Schoelermann AM, Weber TM, Arrowitz C, Rize RL, Qian K, Babcock M. Skin compatibility and efficacy of a cosmetic skin care regimen with licochalcone A and 4-t-butylcyclohexanol in patients with rosacea subtype I. JEADV 2016, 30 (Suppl. 1): 21-27
  • Kuhlmann M, Ekanayake-Bohling S, Klensang K, Hartkopf C, Saladin S, Wigger-Alberti W. Local tolerability and wound healing properties of two waterproof dressings for post-operative care after minor surgery. Congress of the European Wound Management Association, EWMA, Bremen, Germany, 2016 (Poster sub)
  • Kuhlmann M, Klensang K, Manger C, Saladin S. Local tolerability, efficacy and acceptability of a corn plaster with salicylic acid in the treatment of corns. FIP World Congress of Podiatry, 2016 (Poster sub)
  • Schweiger D, Hoff A, Scheede S, Fischer F, Tilsner J, Lüttke J, Neumann Y, Hagens R. Towards a Body Hair Atlas of Women of Caucasian Ethnicity. Int J Cosmet Sci. 38(4): 409-420, 2016
  • Halm M, Schenke-Layland K, Jaspers S, Wenck H, Fischer F: Visualizing tropoelastin in a long-term human elastic fibre cell culture model. Sci Rep. 2016; 6: 20378.
  • Kwiatkowski M, Wurlitzer M, Krutilin A, Kiani P, Nimer R, Omidi M, Mannaa A, Bussmann T, Bartkowiak K, Kruber S, Uschold S, Steffen P, Lübberstedt J, Küpker N, Petersen H, Knecht R, Hansen NO, Zarrine-Afsar A, Robertson WD, Miller RJ, Schlüter H: Homogenization of tissues via picosecond-infrared laser (PIRL) ablation: Giving a closer view on the in-vivo composition of protein species as compared to mechanical homogenization. J Proteomics. 134: 193-202, 2016.
  • Mellem D, Fischer F, Jaspers S, Wenck H, Rübhausen M: Quality Saving Mechanisms of Mitochondria during Aging in a Fully Time-Dependent Computational Biophysical Model. PLoS ONE. 2016; 11(1): e0146973.
  • Sieg R, Bautsch J, Ullrich O, Fischer F. Revelations of Cell Health Through Super-Resolution Imaging of Mitochondrial Networks. 2016, Poster, Studierendentage Hamburg.