STUDIES & PUBLICATIONS 2021 – TODAY

“Publish or perish” is a well-known phrase among scientists. This means that a major part of research is publicizing your own scientific findings within the scientific community. On the one hand, this serves to provide information about scientific progress, so that others can continue researching based on the latest findings. On the other hand, publishing work, particularly in scientific trade journals, serves to guarantee the quality of your own work and build a relationship with the scientific community. This is because trade journals only publish articles that have withstood a critical examination by recognized experts. For decades Beiersdorf has published its research findings in high-quality, accredited scientific trade magazines as well as in the form of lectures and posters at trade congresses, and as such, opens itself up to the critical opinion of the scientific community. The large number of publications since 1990 quite impressively demonstrates the weight Beiersdorf Research has in the world of global skin research.

• Bienkowska et. al., Frontiers in Aging, 11 January 2024, Sec. Genetics, Genomics and Epigenomics of AgingVolume 4 - 2023 | https://doi.org/10.3389/fragi.2023.1258183

• Ruvolo E, Boothby-Shoemaker W, Kumar N, Hamzavi IH, Lim HW, Kohli I. Evaluation of efficacy of antioxidant-enriched sunscreen products against long wavelength ultraviolet A1 and visible light. Int. J. Cosmet. Sci. 2022, 44: 394-402 https://doi.org/10.1111/ics.12785
• Lyons AB, Zubair R, Kohli I, Nahhas AF, Braunberger TL, Mokhtari M, Ruvolo E, Lim HW, Hamzavi IH. Mitigating visible light and long wavelength UVA1-induced effects with topical antioxidants. Photochem. Photobiol. 2022, 98: 455-460 https://doi.org/10.1111/php.13525
• Lim HW, Kohli I, Ruvolo E, Kolbe L, Hamzavi I. Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection. J. Amer. Acad. Dermatol. 2022; 86: S27-37 https://doi.org/10.1016/j.jaad.2021.12.024
• Rigel D, Lim HW, Draelos Z, Weber TM, Taylor S. Photoprotection for all: Current gaps and opportunities. J. Amer. Acad. Dermatol. 2022; 86: S18-26 https://doi.org/10.1016/j.jaad.2021.12.023
• Moeller N, Vogelsang A, Sperling G, Weise J, Schoelermann A, Gallinger J, Kolbe L, Schulze M. Medical Device sunscreen with SPF 100 is superior to SPF 50+ sun product regarding protection against UV stress-induced inflammation and cell death in vitro. Poster, 31st EADV Congress, Milano 2022
• Weise J, Möller N, Wensorra U, Mann T, Eggers K, Warnke K, Kolbe L. Licochalcone A efficiently protects against HEVIS-induced hyperpigmentation. Poster, 31st EADV Congress, Milano 2022
• Warnke K, Meiring U, Meyer M, Fuerstenau M, Muhr G, Keyhanian S. Improving skin complexion for ultimate glow and radiant skin, combining liquid crystalline technology with an effective tyrosinase inhibitor. Poster, 31st EADV Congress, Milano 2022
• Geloven van A, Harbig S, Stuhr A, Dunckel J, Muhr G, Fürstenau M, Rauscher C, Warnke K. A novel topical approach for mature aging skin to improve all 4 skin quality EPCs for younger looking skin. Poster, 31st EADV Congress, Milano 2022
• Weise J, Vogelsang A, Sperling G, Welge V, Nölter A, Mielke H, Knott A, Harbig S, Stuhr A, Dunckel J, Warnke K, Geloven van A. Inhibition of extracellular matrix degrading enzymes and bio-stimulation of fibroblasts – A novel approach to mitigate the advanced degenerative process in skin aging. Poster, 31st EADV Congress, Milano 2022
• Worthmann A, Sammain A, Friemauth T, Zoellner D, Mireles W, Ballona R. How to improve symptoms of atopic dermatitis and maintain the flare-up free phase in babies & kids. Poster, 31st EADV Congress, Milano 2022
• Mießner H, Seidel J, Smith E St John. In vitro models for investigating itch. Front. Mol. Neurosci. 2022, 15: 984126 https://doi.org/10.3389/fnmol.2022.984126
• Altgilbers S, Rippke F, Filbry A, Conzelmann S, Vietzke J-P, Burkhardt T, Segger D, Roggenkamp D, Grönniger E. A biomimetic combination of actives enhances skin hydration and barrier function via modulation of gene expression: Results of two double-blind, vehicle-controlled clinical studies. Skin Pharmacol. Physiol. 2022; 35: 102–111 https://doi.org/10.1159/000520009
• Gallinger J, Kuhn A, Wessel S, Behm P, Heinecke S, Filbry A, Hillemann L, Rippke F. Depth-dependent hydration dynamics in human skin – Vehicle-controlled efficacy assessment of a functional 10% Urea plus NMF moisturizer by Near-Infrared Confocal Spectroscopic Imaging (KOSIM IR) and capacitance method complemented by volunteer perception. Skin Res. Technol. 2022; 28: 342–349 https://doi.org/10.1111/srt.13137
• Bluemke A, Ring AP. Immeyer J, Hoff A, Eisenberg T, Gerwat W, Meyer F, Breitkreutz S, Klinger LM, Brandner JM, Sandig G, Seifert M, Segger D, Rippke F, Schweiger D. Multidirectional activity of bakuchiol against cellular mechanisms of facial ageing - Experimental evidence for a holistic treatment approach. Int. J. Cosmet. Sci. 2022, 44: 377–393 https://doi.org/10.1111/ics.12784
• Weber TM, Rippke F, Groenniger E, Schoelermann AM. Hand and foot moisturizers. In: Cosmetic Dermatology: Products and Procedures. Ed. Draelos ZD. John Wiley & Sons Ltd. 2022: 189-199
• Ahle CM, Stødkilde K, Poehlein A, Bömeke M, Streit WR, Wenck H, Reuter JH, Hüpeden J, Brüggemann H. Interference and co-existence of staphylococci and Cutibacterium acnes within the healthy human skin microbiome. Commun. Biol. 2022, 5: 923 https://doi.org/10.1038/s42003-022-03897-6
• Ahlers JMD, Falckenhayn C, Holzscheck N, Solé-Boldo L, Schütz S, Wenck H, Winnefeld M, Lyko F, Grönniger E, Siracusa A. Single-cell RNA profiling of human skin reveals age-related loss of dermal sheath cells and their contribution to a juvenile phenotype. Front. Genetics 2022, 12: 797747 https://doi.org/10.3389/fgene.2021.797747
• Gather L, Nath N, Falckenhayn C, Oterino-Sogo S, Bosch T, Wenck H, Winnefeld M, Grönniger E, Simm S, Siracusa A. Macrophages are polarized toward an inflammatory phenotype by their aged microenvironment in the human skin. J. Invest. Dermatol. 2022, 142: 3136-3145 https://doi.org/10.1016/j.jid.2022.06.023
• Staufer T, Schulze ML, Schmutzler O, Körnig C, Welge V, Burkhardt T, Vietzke J-P, Vogelsang A, Weise JM, Blatt T, Dabrowski O, Falkenberg G, Brückner D, Sanchez-Cano C, Grüner F. Assessing cellular uptake of exogenous Coenzyme Q10 into human skin cells by X-ray fluorescence imaging. Antioxidants 2022, 11: 1532 https://doi.org/10.3390/antiox11081532
• Vogelsang A, Sperling G, Dunckelmann K, Bussmann T, Fischer F, Wenck H, Blatt T, Weise JM. Anti-aging active Q10’s protective role against stress induced mitochondrial fragmentation in skin cells. Poster, 10th ICQA Conference, Hamburg 2022
• de Ligt R, Westerhout J, Grossouw D, Buters TP, Rissmann R, Burggraaf J, Windhorst AD, Tozer S, Pappa G, Wall B, Bury D, Mason DR, Vaes WHJ. Assessment of dermal absorption of aluminium from a representative antiperspirant formulation using a (26Al) Al microtracer approach: a follow-up study in human. Toxicol. Res. 2022, 11: 511–519 https://doi.org/10.1093/toxres/tfac029 
• Najjar A, Ellison CA, Gregoire S, Hewitt NJ. Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data. Arch. Toxicol. 2022, online ahead of print https://doi.org/10.1007/s00204-022-03371-6
• Najjar A, Punt A, Wambaugh J, Paini A, Ellison C, Fragki S, Bianchi E, Zhang F, Westerhout J, Mueller D, Li H, Shi Q, Gant TW, Botham P, Bars R, Piersma A, van Ravenzwaay B, Kramer NI. Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro‑to‑in vivo extrapolation (IVIVE) in chemical risk assessment. Arch. Toxicol. 2022, 96: 3407–3419 https://doi.org/10.1007/s00204-022-03356-5
• Najjar A, Schepky A, Krueger C-T, Dent M, Cable S, Li H, Grégoire S, Roussel L, Noel-Voisin A, Hewitt NJ, Cardamone E. Use of physiologically-based kinetics modelling to reliably predict internal concentrations of the UV filter, homosalate, after repeated oral and topical application. Front. Pharmacol. 2022, 12: 802514 https://doi.org/10.3389/fphar.2021.802514
• Hamadeh A, Troutman J, Najjar A, Edginton A. A mechanistic bayesian inferential workflow for estimation of in vivo skin permeation from in vitro measurements. J. Pharm. Sci. 2022, 111 (3): 838-851 https://doi.org/10.1016/j.xphs.2021.11.028
• Ouedraogo G, Alexander-White C, Bury D, Clewell III HJ, Cronin M, Cull T, Dent M, Desprez B, Detroyer A, Ellison C, Giammanco S, Hack E, Hewitt NJ, Kenna G, Klaric M, Kreiling R, Lester C, Mahony C, Mombelli E, Naciff J, O’Brien J, Schepky A, Tozer S, van der Burg B, van Vugt-Lussenburg B, Stuard S, Cosmetics Europe. Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens. Regul. Toxicol. Pharmacol. 2022, 132: 105161 https://doi.org/10.1016/j.yrtph.2022.105161
• Hoffmann S, Alepee N, Gilmour N, Kern PS, van Vliet E, Boisleve F, Bury D, Cloudet E, Klaric M, Kühnl J, Lalko JF, Mewes K, Miyazawa M, Nishida H, Brami MTT, Varçin M, Api AM, Cosmetics Europe. Expansion of the Cosmetics Europe skin sensitisation database with new substances and PPRA data. Regul. Toxicol. Pharmacol. 2022, 131: 105169 https://doi.org/10.1016/j.yrtph.2022.105169
• Alexander-White C, Bury D, Cronin M, Dent M, Hack E, Hewitt NF, Kenna G, Naciff J, Ouedraogo G, Schepky A, Mahony C, Cosmetics Europe. A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment. Regul. Toxicol. Pharmacol. 2022, 129: 105094 https://doi.org/10.1016/j.yrtph.2021.105094
• Hewitt NJ, Troutman J, Przibilla J, Schepky A, Ouedraogo G, Mahony C, Kenna G, Varçin M, Dent MP, Cosmetics Europe. Use of in vitro metabolism and biokinetics assays to refine predicted in vivo and in vitro internal exposure to the cosmetic ingredient, phenoxyethanol, for use in risk assessment. Regul. Toxicol. Pharmacol. 2022, 131: 105132 https://doi.org/10.1016/j.yrtph.2022.105132
• Burbank M, Hewitt NJ, Kenna G, Kukic P, Boettcher M, Ebmeyer J, Mahony C, Armstrong D, Willox I, Otto-Bruc A, Paul-Friedman K, Ouédraogo G. In vitro pharmacologic profiling for cosmetic chemical systemic toxicity safety testing: preliminary data. Poster, 16th ICT, Maastricht 2022 Toxicol. Letters 2022, 368: S289 https://doi.org/10.1016/j.toxlet.2022.07.758 
• Burbank M, Hewitt NJ, Kenna G, Boettcher M, Ebmeyer J, Mahony C, Kukic P, Armstrong D, Noel-Voisin A, Gautier F, Golbamaki N, Grégoire S, Detroyer A, Riu A, Ouédraogo G. In vitro pharmacologic profiling for cosmetic chemical systemic toxicity safety testing: a case study on homosalate. Poster, 21st ESTIV Congress, Barcelona 2022 Abstract book, Eds. Kandarova H, Barroso J. 2022, 81: 336
• Tiwari N, Osorio-Blanco ER, Sonzogni A, Esporrin-Ubieto D, Wang H, Calderon M. Nanocarriers for skin applications: where do we stand? Angew. Chem. Int. Ed. 2022, 61: e202107960 http://dx.doi.org/10.1002/anie.202107960
  http://dx.doi.org/10.1002/ange.202107960
  

• Roggenkamp D, Dlova N, Mann T, Batzer J, Riedel J, Kausch M, Zoric I, Kolbe L. Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol). Int. J. Cosmet. Sci. 2021; 43: 292-301 https://doi.org/10.1111/ics.12694
• Roggenkamp D, Sammain A, Fürstenau M, Kausch M, Passeron T, Kolbe L. Thiamidol® in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase. J. Dermatol. 2021; 48 (12): 1871-1876 https://doi.org/10.1111/1346-8138.16080
• Laudien M, Wensorra U, Roggenkamp D, Kolbe L, Schmidt L, Gallinger J, Warnke K, Weise J. Licochalcone A as powerful active partner for Thiamidol: Dual action against hyperpigmentation. Poster, 30^th EADV Congress, Vienna 2021
• Gallinger J, Rauscher C, Kuhn A, Dippe R, Dorsch S, Buerger A. Addressing an unmet cosmetical need: Effective solution to reduce both blemishes and acne-related post-inflammatory hyperpigmentation with a novel skin care formulation tailored for acne-prone skin containing the tyrosinase inhibitor Thiamidol. Poster, 30^th EADV Congress, Vienna 2021
• Gallinger J, Rauscher C, Kuhn A, Dippe R, Noelter A, Baumann S, Dorsch S, Buerger A. When 2 become 1: Effective reduction and prevention of blemishes and acne-related postinflammatory hyperpigmentation by two new formulations tailored for acne-prone skin combining Thiamidol efficacy, UV protection and antibacterial effect for improved quality of life. Poster, 30^th EADV Congress, Vienna 2021
• Kobylinski S, Reble C, Schanzer S, Gersonde I, Wiora G, Ploch NL, Karrer H, Kolbe L, Khazaka G, Lademann J, Meinke MC. Noninvasive measurement of the 308 nm LED-based UVB protection factor of sunscreens. J. Biophotonics 2021; 14: e202000453 https://doi.org/10.1002/jbio.202000453
• Throm CM, Wiora G, Reble C, Schleusener J, Schanzer S, Karrer H, Kolbe L, Khazaka G, Meinke MC, Lademann J. In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi-lambda-LED light source. J. Biophotonics. 2021;14: e202000348 https://doi.org/10.1002/jbio.202000348
• Ruvolo E, Rohr M, Oliveira S, Nogueira L, Carvalho J, Cole C. Multi-laboratory study of hybrid diffuse reflectance spectroscopy to assess sunscreen SPF and UVA-PF. Photodermatol. Photoimmunol. Photomed. 2021; 37: 511–520 https://doi.org/10.1111/phpp.12703
  
• Batzer J, Möller N, Bürger A, Balcke I, Kaack J, Wedel-Parlow M, Gallinger J, Weise J, Warnke K. Comparison of two in vitro methods regarding determination of physical protection against HEVIS stress. Poster, 30^th EADV Congress, Vienna 2021
• Warnke K, Möller N, Batzer J, Bürger A, Balcke I, Drescher P, Muhr G, Gallinger J, Weise J. More than sun protection – Combining Licochalcone A and color pigments for dual HEVIS protection. Poster, 30^th EADV Congress, Vienna 2021
• Gallinger J, Kohlhase S, Batzer J, Jung K, Bahr K, Kuhlmann I, Heinsohn G, Moeller N, Weise J, Buerger A, Schoelermann AM. Novel Medical Device with SPF 100 and very light and fluid texture developed for prevention of actinic keratosis and non-melanoma skin cancer. Poster, 30^th EADV Congress, Vienna 2021
• Schmidt L, Meiring U, Djamil J, Kuschel D, Drescher P, Dippe R, Warnke K. Closing a need gap – Effective dermocosmetic hand care targeting photoaging including lentigines solares with first visible results after 2 weeks. Poster, 30^th EADV Congress, Vienna 2021
• Zieger M, Kaatz M, Springer S, Riesenberg R, Wuttig A, Kanka M, Stanca S, Reble C, Khazaka G, Sieg R, De Gregorio M, Sattler M, Fischer F. Multi-wavelength, handheld laser speckle imaging for skin evaluation. Skin Res. Technol. 2021; 27: 486–493 https://doi.org/10.1111/srt.12959
• Kern C, Speck U, Riesenberg R, Reble C, Khazaka G, Zieger M, Kaatz M, De Gregorio M, Fischer F. Mobile snapshot hyperspectral imaging device for skin evaluation using diffractive optical elements. Skin Res. Technol. 2021; 27: 589–598 https://doi.org/10.1111/srt.12991
• Akinsinde LO, Glier TE, Schwartzkopf M, Betker M, Nissen M, Witte M, Scheitz S,  Nweze C, Grimm-Lebsanft B, Gensch M, Chumakov A, Baev I, Schürmann U, Dankwort T, Fischer F, Martins M, Roth SV, Kienle L, Rübhausen M. Surface characterization and resistance changes of silver-nanowire networks upon atmospheric plasma treatment. Appl. Surface Sci. 2021; 550: 149362 https://doi.org/10.1016/j.apsusc.2021.149362 
• Holzscheck N, Falckenhayn C, Söhle J, Kristof B Siegner R, Werner A, Schössow J,  Jürgens C, Völzke H, Wenck H, Winnefeld M, Grönniger E, Kaderali L. Modeling transcriptomic age using knowledge-primed artificial neural networks. NPJ Aging Mechan. Disease 2021; 7:15 https://doi.org/10.1038/s41514-021-00068-5
• Witte M, Rübhausen M, Jaspers S, Wenck H, Fischer F. A method to analyze the influence of mechanical strain on dermal collagen morphologies. Sci. Rep. 2021; 11: 7565 https://doi.org/10.1038/s41598-021-86907-7
• Bussmann T, Warnke K, Krüger A, Möller N, Harbig S, Stuhr A, Dunckel J, Geloven van A, Weise J. Multifaceted novel approach to increase skin’s own epidermal and dermal hyaluron content. Poster, 30^th EADV Congress, Vienna 2021
• Geloven van A, Harbig S, Stuhr A, Dunckel J, Kuhn A, Dippe R, Warnke K. A holistic hyaluron-centric anti-aging concept to improve static and dynamic wrinkles. Poster, 30^th EADV Congress, Vienna 2021
• Worthmann A, Wessel S, Fuerstenau M, Schoelermann A, Gallinger J. Tailored for sensitive skin: A cleansing formulation with pH 5 mildly cleanses and protects sensitive skin and its microbiome. Poster, 30^th EADV Congress, Vienna 2021
• Schmidt L, Drescher P, Friemauth T, Ernst C, Sammain A, Gallinger J. A perfect match: The gold standard for dry skin plus anti-xerotic actives combined with a pleasant foam formulation – a holistic care approach for dry feet also in diabetes patients. Poster, 30^th EADV Congress, Vienna 2021
• Nickel K, Wensorra U, Wenck H, Peters N, Genth H. Evaluation of immunomodulatory responses and changed wound healing in type 2 diabetes—A study exploiting dermal fibroblasts from diabetic and non-diabetic human donors. Cells 2021; 10: 2931 https://doi.org/10.3390/cells10112931
• Ahle CM, Stødkilde-Jørgensen K, Poehlein A, Streit WR, Hüpeden J, Brüggemann H. Comparison of three amplicon sequencing approaches to determine staphylococcal populations on human skin. BMC Microbiol. 2021; 21: 221 https://doi.org/10.1186/s12866-021-02284-1
• Marcheggiani F, Kordes S, Cirilli I, Orlando P, Silvestri S, Vogelsang A, Moller N, Blatt T, Weise JM, Damiani E, Tiano L. Anti-ageing effects of ubiquinone and ubiquinol in a senescence model of human dermal fibroblasts. Free Rad. Biol. Med. 2021; 165: 282-288 https://doi.org/10.1016/j.freeradbiomed.2021.01.032
• Nicol NH, Rippke F, Weber TM, Hebert AA. Daily moisturization for atopic dermatitis: Importance, recommendations, and moisturizer choices. J. Nurse Pract. 2021; 17: 920-925 https://doi.org/10.1016/j.nurpra.2021.06.003
• Kordes S, Schulze M, Plennis A, Gallinger J, Filbry A, Weise J, Rippke F, Altgilbers S. Licochalcone A prevents inflammation-induced down-regulation of filaggrin gene expression in a 2D in vitro atopic dermatitis model. Poster, 30^th EADV Congress, Vienna 2021
• Laudien M, Welge V, Prokop M, Filbry A, Gallinger J, Weise J, Rippke F, Schulze M. A multifunctional moisturizer containing 10% urea plus NMF normalizes down-regulated epidermal gene expression in winter xerosis – Results of a novel in vitro approach. Poster, 30^th EADV Congress, Vienna 2021
  
• von Martial S, Nippel G, Schmidt L, Sammain A, Schölermann A, Presto S, Tsianakas A. Einfluss einer adjuvanten Basistherapie mit 10% Urea, Ceramiden, Glycerin und Glyceryl Glucoside bei Patienten mit Psoriasis vulgaris. Hautarzt 2021; 72: 892–899 https://doi.org/10.1007/s00105-021-04833-1
•  Gregoire S, Sorrell I, Lange D, Najjar A, Schepky A, Ellison C, Troutman J, Fabian E, Duplan H, Genies C, Jacques-Jamin C, Klaric M, Hewitt NJ. Cosmetics Europe evaluation of 6 in silico skin penetration models. Comput. Toxicol. 2021; 100177 https://doi.org/10.1016/j.comtox.2021.100177
  
• Bury D, Alexander-White C, Clewell III HJ, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A. New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine. Regul. Toxicol. Pharmacol. 2021; 123: 104931 https://doi.org/10.1016/j.yrtph.2021.104931
• Lester C, Hewitt NJ, Müller-Vieira U, Mayer M, Ellison C, Duplan H, Genies C, Jacques-Jamin C, Fabian E, Sorrell I, Lange D, Schepky A Gregoire S. Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models. Toxicol. in Vitro 2021; 72: 105051 https://doi.org/10.1016/j.tiv.2020.105051
• Ouedraogo G, Mahony C, Naciff J, Klaric M, Hewitt NJ, Kenna G, Schepky A, Krüger CT, Dent M, Vandenbossche E, Keller D. Integrating toxicokinetics and toxicodynamics for decision-making in an NGRA context: 2 Cosmetics-Europe case studies (abstr. 377).  MECC Maastricht 2021
• Ellison CA, Api AM, Becker RA, Efremenko AY, Gadhia S, Hack CE, Hewitt NJ, Varcin M, Schepky A. Internal threshold of toxicological concern (iTTC): Where we are today and what is possible in the near future. Front. Toxicol. 2021; 2: 621541 https://doi.org/10.3389/ftox.2020.621541
• Adriaens E, Verstraelen S, Desprez B, Alepee N, Abo T, Bagley D, Hibatallah J, Mewes KR, Pfannenbecker U, Van Rompay AR. Overall performance of Bovine Corneal Opacity and Permeability (BCOP) Laser Light-Based Opacitometer (LLBO) test method with regard to solid and liquid chemicals testing. Toxicol. In Vitro 2021; 70: 105044 https://doi.org/10.1016/j.tiv.2020.105044
• Kühnl J, Tao TP, Brandmair K, Gerlach S, Rings T, Müller-Vieira U, Przibilla J, Genies C, Jaques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I. Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model. Toxicol. 2021; 448: 152637 https://doi.org/10.1016/j.tox.2020.152637
• Tao TP, Brandmair K, Gerlach S, Przibilla J, Géniès C, Jacques-Jamin C, Schepky A, Marx U, Hewitt NJ, Maschmeyer I, Kühnl J. Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin–liver microphysiological model. J. Appl. Toxicol 2021; 41:1553–1567 https://doi.org/10.1002/jat.4146
• Wilm A, Norinder U, Agea MI, de Bruyn Kops C, Stork C, Kühnl J, Kirchmair J. Skin Doctor CP: Conformal prediction of the skin sensitization potential of small organic molecules. Chem. Res. Toxicol. 2021; 34: 330-344 https://dx.doi.org/10.1021/acs.chemrestox.0c00253
• Wilm A, de Lomana MG, Stork C, Mathai N, Hirte S, Norinder U, Kühnl J, Kirchmair J. Predicting the skin sensitization potential of small molecules with machine learning models trained on biologically meaningful descriptors. Pharmaceuticals 2021; 14: 790 https://doi.org/10.3390/ph14080790